Figure 2
From: Inhibition of protein geranylgeranylation induces apoptosis in synovial fibroblasts
Statins decrease the viability of synovial fibroblasts in a time-dependent manner. Synovial fibroblasts were cultured for 24, 48, 72 and 96 hours in the presence of 10 μM atorvastatin, 10 μM simvastatin or 3 μM cerivastatin. XTT assays were then performed on quadruplicate wells to determine the percentage cellular viability of statin-treated cultures in comparison with those treated with the vector under identical conditions. Results are representative of two experiments.