Figure 5From: A model of anti-angiogenesis: differential transcriptosome profiling of microvascular endothelial cells from diffuse systemic sclerosis patientsImpairment of angiogenesis in systemic sclerosis. Genes differentially expressed in microvascular endothelial cells (MVECs) from patients with systemic sclerosis (SSc-MVECs) are grouped according to Table 3. Upward and downward arrows indicate up-regulation and down-regulation, respectively, in SSc-MVECs. Differentially expressed genes that we propose to be critical to the altered angiogenic process in SSc are reported in italics in each sub-group. In SSc, the powerful angiogenic instruction of Vascular Endothelial Growth Factor (VEGF) and Fibroblast Growth Factor-2 (FGF2) [34,35] is outstripped by the activity of differentially expressed genes shown as a separate group in the box shaded light grey.Back to article page