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Figure 6 | Arthritis Research & Therapy

Figure 6

From: Induction of multiple matrix metalloproteinases in human dermal and synovial fibroblasts by Staphylococcus aureus: implications in the pathogenesis of septic arthritis and other soft tissue infections

Figure 6

Matrix metalloproteinase (MMP) mRNA induction by staphylococcal accessory regulator (Sar), accessory gene regulator (Agr), and Sar/Agr mutants of Staphylococcus aureus. MMP-1 and MMP-3 mRNAs in confluent monolayers of human dermal fibroblasts exposed to 25 μg of total protein/well per milliliter from cell lysate and 25 μg/well per milliliter of total protein from culture supernatants (SUP) of parent (U1) mutant strains (U155 Sar-/-; U929 Agr-/-; U930 Sar/Agr-/-) were measured by SYBR green real-time reverse transcription-polymerase chain reaction 8 hours after exposure. No significant differences in mRNA levels of MMP-1 and MMP-3 induced by the mutants and their isogenic parent strain were observed.

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Arthritis Research & Therapy

ISSN: 1478-6362

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