Skip to main content
Figure 4 | Arthritis Research & Therapy

Figure 4

From: Novel self-epitopes derived from aggrecan, fibrillin, and matrix metalloproteinase-3 drive distinct autoreactive T-cell responses in juvenile idiopathic arthritis and in health

Figure 4

Relation of disease duration and T-cell proliferative responses induced by aggrecan, fibrillin, and matrix metalloproteinase (MMP)-3. Proliferative activity of peripheral blood mononuclear cells from patients with juvenile idiopathic arthritis was dichotomized as follows: stimulation index (SI)-non-responsive < 2 ≤ SI-responsive. Responders to the aggrecan peptide had the lowest disease duration (p = 0.016). Responders to the MMP-3 peptide showed a similar trend, which was close to reaching statistical significance (p = 0.056). Black bars: responders; transparent bars: non-responders. Asterisk indicates significant difference.

Back to article page

Arthritis Research & Therapy

ISSN: 1478-6362

Contact us