Figure 3From: The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritisEffect of macrophage depletion on cytokine and matrix metalloproteinase (MMP) production in osteoarthritis (OA) synovial cells. OA cultures of synovial cells were either left intact or macrophage-depleted, as described in Materials and methods. Cells were left to adhere for 24 hours before the supernatants were removed for enzyme-linked immunosorbent assay analysis of cytokines and MMPs. Data are expressed as the percentage of cytokine/MMP production in the depleted culture as compared with the undepleted one. The standard error of the mean is given (n = 7–9). IL, interleukin; MCP, monocyte chemoattractant protein; TNF, tumour necrosis factor.Back to article page