Skip to main content

Table 5 Genes significantly upregulated or downregulated in lipopolysaccharide-challenged groups 2, 3, and 4

From: Effects of hyaluronan treatment on lipopolysaccharide-challenged fibroblast-like synovial cells

Full or provisional gene annotation (accession number)

Function or activity in joint inflammationa

Fold change

Pair-wise comparisons (adjusted P values)

  

Group 3/group 2

Group 4/group 2

Group 3 vs group 2

Group 4 vs group 2

IL-6 (U64794)

Proinflammatory mediator [46]

0.45

0.34

0.0015

0.0015

Matrix metalloproteinase 13 (AF034087)

Connective tissue structure and remodeling [40]

0.10

0.11

0.0039

0.0005

Cathepsin S (CD468903)

Proteolysis and matrix degradation [47]

0.47

0.57

0.0022

0.0005

Manganese superoxide dismutase (BM734930)

Antioxidant [48]

0.62

0.71

0.0040

0.0040

Manganese superoxide dismutase (BI960803)

 

0.50

0.64

0.0117

0.0024

Matrix metalloproteinase 1 (AF148882)

Connective tissue structure and remodeling [40]

0.32

0.35

0.0050

0.0003

Matrix metalloproteinase 3 (U62529)

Connective tissue structure and remodeling [40]

0.24

0.19

0.0035

0.0051

Guanine nucleotide binding protein alpha inhibiting 1 (CD465125)

G-protein signaling, adenylate cyclase inhibitor [49]

0.62

0.66

0.0079

0.0046

V-maf oncogene (BM735497)

Unknown

0.60

0.59

0.0035

0.0095

Inhibitor of DNA binding 2 dominant negative helix–loop–helix protein (CD536136)

Positive regulation of cell proliferation [50]

0.60

0.66

0.0172

0.0038

Plasminogen activator inhibitor 1 (BM780455)

Inhibitor of proteolytic activity in rheumatoid arthritis [51,52]

2.93

2.59

0.0002

<0.0001

Plasminogen activator inhibitor 1 (AF508034)

 

2.11

2.15

0.0025

<0.0001

hnRNP core protein A1 (CD469785)

Target of antinuclear autoimmunity in rheumatoid arthritis [41]

1.41

1.40

0.0114

0.0028

Aurora-A kinase interacting protein 1 (BM735310)

Positive regulator of proteolysis

1.31

1.35

0.0215

0.0044

Dyskerin (CD536222)

RNA binding, processing, and modification

2.30

1.74

0.0046

0.0028

Cyclin D2 (CD467520)

Induced by type I interferons after lipopolysaccharide exposure; cell cycle regulation

1.24

1.50

0.0500

0.0020

Isoleucine tRNA synthetase (CD535292)

Isoleucyl-rRNA aminocylation

1.36

1.50

0.0254

0.0015

Nuclear ubiquitous casein kinase 2 (CD535471)

Kinase in NF-κB cascade [53]

1.62

1.55

0.0294

0.0048

Eukaryotic translation initiation factor 5 (BM781180)

Translation initiation factor

1.95

1.33

0.0048

0.0050

Eukaryotic translation initiation factor 5 (CD465311)

 

2.26

1.55

0.0146

0.0013

Unknown (BM780356)

Unknown

1.28

1.55

0.0316

0.0011

  1. Three individual donors are represented for each group. aBased on the Gene Ontology Database description and the literature (see references). Statistically significant P values are in bold. Group 2, lipopolysaccharide control; group 3, pretreatment and sustained treatment with lower molecular weight hyaluronan product; group 4, pretreatment and sustained treatment with higher molecular weight hyaluronan product.
Back to article page

Arthritis Research & Therapy

ISSN: 1478-6362

Contact us