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Figure 4 | Arthritis Research & Therapy

Figure 4

From: Fibroblast-like synovial cells from normal and inflamed knee joints differently affect the expression of pain-related receptors in sensory neurones: a co-culture study

Figure 4

Influence of fibroblast-like synovial (FLS) cells on bradykinin 2 (B2) receptor-like labelling in dorsal root ganglion (DRG) neurones. (a) Co-culture of DRG neurones and FLS cells isolated after induction of acute antigen-induced arthritis (AIA). Dark DRG neurones (arrows) show bradykinin-gold labelling. (b) Same cells as in (a) double-labelled with an anti-neurone-specific enolase antibody. Scale bar, 10 μm. (c) Influence of FLS cells isolated from normal, acutely or chronically inflamed knees on B2 receptor-like labelling in DRG neurones. #Significant difference to DRG mono-cultures. $Significant difference to co-culture with FLS cells from normal knee joints. AIA, antigen-induced arthritis.

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Arthritis Research & Therapy

ISSN: 1478-6362

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