From: Tumor metastasis to bone
Tumor-secreted factors | Probable mechanisms underlying new bone formation in osteoblastic metastases |
---|---|
Wnt | Stimulates differentiation and activation, and promotes survival and activity of osteoblasts; inhibits osteoclast activity [52] |
ET-1 | Stimulates proliferation of osteoblasts, promotes mineralization, inhibits osteoclast motility, and potentiates the pro-osteogenic effects of other growth factors [59,60] |
BMP | Stimulates osteoblast proliferation, activity, and survival; increases OPG production [62-66] |
IGF-1, IGF-2 | Stimulate osteoblast proliferation and survival [87] |
IL-6 | Regulates osteoblast function [88] |
OPG | Inhibits osteoclastic activity by binding to RANKL [89] |
TGF-β | Stimulates osteoblast proliferation [90] |
Urokinase (uPA) | Stimulates osteoblast proliferation [91] |
PDGF-BB | Promotes angiogenesis and osteoblast activity [92] |
FGF-1, FGF-2, and FGF-8 | Promote differentiation and proliferation of osteoblasts [93] |
PSA | Inactivation of PTHrP and stimulation of latent growth factors (TGF-β) [94] |
VEGF | Promotes osteoblast differentiation [95] |
MDA-BF-1 | Stimulates osteoblast formation and activation [96] |