Figure 6

YC-1 mediated inhibition of hypoxic induction of P4H in meniscus cell aggregates. Ratio of hypoxia (5% oxygen) induced prolyl 4-hydroxylase (P4H)α(I) gene expression (post-normalization to β-actin) to P4Hα(I) gene expression (post-normalization to β-actin) in 20% oxygen in monolayer culture of meniscus cells in the presence and absence of the hypoxia inducible factor-1α inhibitor YC-1. Data are expressed as mean ± standard deviation (n = 3).