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Figure 4 | Arthritis Research & Therapy

Figure 4

From: Identification of an altered peptide ligand based on the endogenously presented, rheumatoid arthritis-associated, human cartilage glycoprotein-39(263–275) epitope: an MHC anchor variant peptide for immune modulation

Figure 4

Response of polyclonal lymph node cells from HLA-DR4trg mice immunized with (a) wild-type (wt) peptide or (b) the F265(Dip) altered peptide ligand (APL). Antigen-specific response (proliferation, IFNγ production, upper panel; Mip1α and RANTES production, lower panel) of popliteal lymph node cells from HC gp-39(263–275)-immunized, HLA-DR4 transgenic mice to peptide (wild type and APLs) (a). Antigen-specific response (proliferation, IFNγ production, upper panel; Mip1α and RANTES production, lower panel) of popliteal lymph node cells from MHC variant F265(Dip)-immunized, HLA-DR4trg mice to peptide (F265(Dip), 263–275 wt, HC gp-39 and F265(3Tic)) (b).

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Arthritis Research & Therapy

ISSN: 1478-6362

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