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Figure 2 | Arthritis Research & Therapy

Figure 2

From: Prostaglandin PGE2 at very low concentrations suppresses collagen cleavage in cultured human osteoarthritic articular cartilage: this involves a decrease in expression of proinflammatory genes, collagenases and COL10A1, a gene linked to chondrocyte hypertrophy

Figure 2

Prostaglandin E2 (PGE2) does not affect total proteoglycan release. (a–d) Percentage release of total proteoglycan (glycosaminoglycan (GAG) release) was measured in conditioned media of human osteoarthritic cartilage explants cultured with 5 ng/ml transforming growth factor-β2 or PGE2 at concentrations from 1 pg/ml to 10 ng/ml. The age and sex of each patient are indicated. Significant differences from controls (P < 0.05) are indicated by asterisks.

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Arthritis Research & Therapy

ISSN: 1478-6362

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