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Table 2 Differentially expressed genes in the two congenic intervals

From: The influence of the NOD Nss1/Idd5 loci on sialadenitis and gene expression in salivary glands of congenic mice

Gene ID

Gene symbola

Gene name

Fold changeb

   

B10.Q versus NB

B10.Q versus NBI

NB versus NBI

215627

Zbtb8

Zinc finger and BTB domain containing 8

3.7

4.4

 

384059

Tlr12

Toll-like receptor 12

3.3

  

381549

Zfp69

Zinc finger protein 69

3.2

3.3

 

230779

Serinc2

Serine incorporator 2

3

2.2

 

16818

Lck

Lymphocyte protein tyrosine kinase

2.9

3

 

12260

C1qb

Complement component 1, q subcomponent, beta polypeptide

2.8

1.8

 

23833

Cd52

CD52 antigen

2.5

2

 

12259

C1qa

Complement component 1, q subcomponent, alpha polypeptide

2.4

1.7

 

20846

Stat1

Signal transducer and activator of transcription 1

2.2

1.8

 

14268

Fn1

Fibronectin 1

2.2

1.7

 

14612

Gja4

Gap junction membrane channel protein alpha 4

 

2.2

 

18991

Pou3f1

POU domain, class 3, transcription factor 1

 

2.2

 

11520

Adfp

Adipose differentiation related protein

2.1

1.7

 

107581

Col16a1

Procollagen, type XVI, alpha 1

2.1

1.6

 

269582

Clspn

Claspin homolog (Xenopus laevis)

 

2.1

 

16792

Laptm5

Lysosomal-associated protein transmembrane 5

1.9

1.8

 

12579

Cdkn2b

Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

1.9

1.6

 

20970

Sdc3

Syndecan 3

1.9

1.6

 

20720

Serpine2

Serine (or cysteine) peptidase inhibitor, clade E, member 2

1.8

  

14700

Gng10

Guanine nucleotide binding protein (G protein), gamma 10

 

1.8

 

230657

Tmem69

Transmembrane protein 69

1.7

1.5

 

16008

Igfbp2

Insulin-like growth factor binding protein 2

1.7

  

73723

Sh3bgrl3

SH3 domain binding glutamic acid-rich protein-like 3

1.7

  

93691

Klf7

Kruppel-like factor 7 (ubiquitous)

1.6

 

-1.6

66290

Atp6v1g1

ATPase, H+ transporting, V1 subunit G isoform 1

1.6

  

27981

D4Wsu53e

DNA segment, Chr 4, Wayne State University 53, expressed

1.6

  

17965

Nbl1

Neuroblastoma, suppression of tumorigenicity 1

1.6

  

67103

Ltb4dh

Leukotriene B4 12-hydroxydehydrogenase

  

1.6

230379

Asah3l

N-acylsphingosine amidohydrolase 3-like

  

1.6

19231

Ptma

Prothymosin alpha

1.5

  

68777

Tmem53

Transmembrane protein 53

 

1.5

 

320438

Alg6

Asparagine-linked glycosylation 6 homolog (yeast, alpha-1,3,-glucosyltransferase)

 

1.5

 

101739

Psip1

PC4 and SFRS1 interacting protein 1

  

1.5

230861

Eif4g3

Eukaryotic translation initiation factor 4 gamma, 3

-1.5

-1.7

 

74648

S100pbp

S100P binding protein

-1.5

  

101739

Psip1

PC4 and SFRS1 interacting protein 1

-1.5

  

18710

Pik3r3

Phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)

-1.5

  

67694

Ift74

Intraflagellar transport 74 homolog (Chlamydomonas)

-1.5

  

76850

Eif2c4

Eukaryotic translation initiation factor 2C, 4

 

-1.5

 

19359

Rad23b

RAD23b homolog (S. cerevisiae)

 

-1.5

-1.8

319146

Ifnz

Interferon zeta

  

-1.5

100206

Adprhl2

ADP-ribosylhydrolase like 2

 

-1.6

-1.7

230815

Man1c1

Mannosidase, alpha, class 1C, member 1

 

-1.6

 

67299

Dock7

Dedicator of cytokinesis 7

-1.6

-1.8

 

21885

Tle1

Transducin-like enhancer of split 1, homolog of Drosophila E(spl)

-1.7

  

66902

Mtap

Methylthioadenosine phosphorylase

 

-1.8

 

11363

Acadl

Acetyl-coenzyme A dehydrogenase, long-chain

  

-1.8

71872

Aox4

Aldehyde oxidase 4

-1.9

  

236511

Eif2c1

Eukaryotic translation initiation factor 2C, 1

-2.1

-1.8

 

58864

Tssk3

Testis-specific serine kinase 3

-3.2

  

13370

Dio1

Deiodinase, iodothyronine, type I

-3.4

-2.3

 

66264

Ccdc28b

Coiled coil domain containing 28B

-4.2

-4.3

 

66260

Tmem54

Transmembrane protein 54

-5

-8

 

74754

Dhcr24

24-Dehydrocholesterol reductase

-12.7

-13.8

 
  1. aGenes on chromosome 1 (Idd5) lie within the markers D1Mit48 and D1Mit235, and genes on chromosome 4 (Nss1) lie within the markers D4Mit48 and D4Mit111. Genes with underlined gene symbols are in the Idd5 fragment. Unknown expressed sequence tags and genes with fold change < ± 1.5 were removed. bThe fold change is the relative intensities for each gene from the microarray gene lists B10.Q versus B10.Q.Nss1, B10.Q versus B10.Q.Nss1/Idd5 and B10.Q.Nss1 versus B10.Q.Nss1/Idd5, respectively. Genes with positive fold change were upregulated in the congenic mice, and in B10.Q.Nss1/Idd5 when compared with B10.Q.Nss1. NB, B10.Q.Nss1; NBI, B10.Q.Nss1/Idd5-he and B10.Q.Nss1/Idd5-ho.