Figure 2

Celecoxib induces cell death in rheumatoid arthritis fibroblast-like synoviocytes. Cells were treated at indicated concentrations and times with either celecoxib or staurosporine. Apoptosis was evaluated by fluorescence-activated cell sorting analysis using Annexin V binding and TO-PRO-3 uptake. Values are expressed as the percentage of total cell death (upper panel) or apoptosis (lower panel) and are the mean ± standard error of the mean of three individual experiments.