Figure 1

Oxaliplatin reduces both the incidence and severity of arthritis. Mice challenged with collagen type II were treated with oxaliplatin (10 mg/kg) on day 31 PI Buffered saline solutions served as controls. Significant differences were evident between the oxaliplatin treated group and the control group. Oxaliplatin n = 19 (▪), control n = 20 (▫). (a) An additional dose of oxaliplatin prolonged the duration of reduced arthritis severity but not the incidence of disease. (b) Mice challenged with collagen type II were treated with oxaliplatin (10 mg/kg) on day 31 and day 37 PI NaCl injections served as control. Significant differences in arthritis severity were evident between the oxaliplatin treated group and the control group (p < 0.05). Oxaliplatin n = 18 (▪), control n = 19 (▫). The figures demonstrate the incidence and the mean arthritis score (only sick animals included).