Figure 1
Correlation matrix from original variables measured in NOD and Balb/c mice. Correlation matrix of proteins differently expressed (P < 0.05) between nonobese diabetic (NOD) and Balb/c mice or significantly associated with autoimmune manifestations in NOD (r > 0.6, P < 0.05) sorted according to protein family membership and principal component structure. The lower left triangle displays the coefficients obtained from NOD, and the upper right triangle the values obtained from Balb/c mice. Red indicates positive correlation, and green negative correlation. Colour saturation indicates the strength of the association. Protein names printed in black are variables that could not be fitted in principal component analyses. Red lettering identifies the variable as being a significant part of component 1, blue of component 2, green of component 3, and so on, of the corresponding of protein family. *Variables representing measurements in saliva. The figure was drawn using iVici 0.91. Abbreviations not defined in the text: Apo, apolipoprotein; beta 2GPI, β2-glycoprotein; CRP, C-reactive protein; EGF, epidermal growth factor; FGF, fibroblast growth factor; GM-CSF, granulocyte macrophage colony-stimulating factor; GRO, melanoma growth stimulatory activity protein; LIF, leukaemia inhibitory factor; LTN, lymphotactin; M-CSF, macrophage-colony stimulating factor; MPO, myeloperoxidase; OPN, osteopontin; OSM, oncostatin M; SAP, serum amyloid P; SCF, stem cell factor; SCL, scleroderoderma; TIMP, tissue inhibitor of metalloproteinase; TPO, thrombopoietin; VEGF, vascular endothelial cell growth factor.