Characteristic | ACZ885 | ||||
---|---|---|---|---|---|
0.3 mg/kg (n = 6) | 1.0 mg/kg (n = 6) | 3.0 mg/kg (n = 6) | mg/kg (n = 20) | Placebo (n = 15) | |
Age (years; mean ± SD) | 61 ± 7 | 53 ± 14 | 57 ± 7 | 50 ± 11 | 55 ± 10 |
hsCRP (mg/l; median [range]) | 17.8 (1.6–95.3) | 43.8 (5.8–89.3) | 3.0 (2.0–43.4) | 11.1 (1.5–28.4) | 6.4 (0.2–66.2) |
DAS28 (mean ± SD) | 6.5 ± 0.8 | 6.6 ± 1.2 | 6.7 ± 1.5 | 6.2 ± 0.7 | 6.7 ± 0.6 |
Number of tender joints (mean ± SD) | 17 ± 9.2 | 15 ± 6.2 | 22 ± 8.5 | 17 ± 7.3 | 20 ± 6.3 |
Number of swollen joints (mean ± SD) | 13 ± 6.3 | 12 ± 4.3 | 12 ± 7.4 | 11 ± 4.8 | 12 ± 5.2 |
Methotrexate dose (n/mg median [range])a | |||||
Oral | 6/17.5 (15–25) | 5/15 (10–15) | 4/15 (15–15) | 13/15 (10–22.5) | 5/15 (10–20) |
Parenteral | 0 | 1/10 (10–10) | 2/22.5 (20–25) | 7/15 (10–22.5) | 10/15 (10–25) |