From: Biology and therapy of fibromyalgia. Evidence-based biomarkers for fibromyalgia syndrome
Reference | Year of study | Number of subjects | Number of control | Objective measure | Findings |
---|---|---|---|---|---|
Bondy and colleagues [5] | 1999 | 168 FMS | 115 | 5-HT2A, T102C polymorphism | Different from control, but not significant for specific allele |
Gürsoy and colleagues [6] | 2001 | 58 FMS | 58 | 5-HT2A, T102C polymorphism | Not significant |
Gürsoy and colleagues [7] | 2003 | 61 FMS | 61 | COMT haplotype | Over-representation of LL variant (low activity). Similar to migraine and TMD |
Offenbaecher and colleagues [8] | 1999 | 62 FMS | 110 | 5-HTT | One positive for over-representative SS genotype, one negative study. Suggestion that any association might be related to comorbid psychology |
Gürsoy [9] | 2002 | 53 FMS | 60 mentally healthy | 5-HTT |  |
Yunus and colleagues [4] | 1999 | 40 multicase families | Â | HLA | Linkage to HLA |
Buskila and colleagues [10] | 2004 | Â | Â | Dopamine D4 receptor polymorphism | Decrease in the frequency of the seven-repeat allele in exon III of the D4 receptor gene associated with fibromyalgia. Finding associated with low novelty-seeking personality |