From: Biology and therapy of fibromyalgia. Evidence-based biomarkers for fibromyalgia syndrome
Reference | Year of study | Number of FM patients | Number of control individuals | QST | QST method | Findings |
---|---|---|---|---|---|---|
Staud and colleagues [102] | 2005 | 11 | 12 | PPT: affected and CP | ASC | Decreased PPT (opposite of HC) after exercise |
Sandberg and colleagues [103] | 2005 | 19 | 19 HC, 7 TM | PPT: TP | ASC | FM, TM with decreased PPT |
Montoya and colleagues [104] | 2005 | 12 | 12 | PPT, ERP | ASC | No difference (trend toward FM with decreased PPT). HC with decreased PPTs with repeat stimuli in one session. Decreased PPT for left hand versus right hand. FM decreased PPT in second assessment period (after EEG) |
Laursen and colleagues [105] | 2005 2005 | 10 FM/whiplash, 10 RA, 10 CLBP, 10 endometriosis | 41 | PPT: TP and CP | ASC | FM/whiplash, RA, endometriosis, CLBP with decreased PPT. Correlation between pressure hyperalgesia at lowest PPT sites and physical function impairment and mental health found |
Landis and colleagues [51] | 2004 | 37 | 30 | PPT: TP and CP | ASC | FM women with decreased PPT. PPT correlated with sleep spindle incidence and duration |
Landis and colleagues [106] | 2004 | 33 | 37 | PPT: TP | ASC | FM women with decreased PPT |
Maquet and colleagues [107] | 2004 | 20 | 50 females, 50 males | PPT: TP | ASC | HC with decreased intraindividual variation (FM w/24%). HC females with decreased PPT compared with HC males. FM with decreased PPT compared with HC females. No difference between dominant and nondominant hands. PPT reproducibility and discrimination optimal at gluteal and knee |
Geisser and colleagues [108] | 2003 | 20 | 20 | PPT: TP and CP | ASC | FM with decreased PPT (more statistically significant than HPT). Catastrophizing correlated with decreased PPT. Depression associated with increased PPT |
Yoldas and colleagues [47] | 2003 | 11 | 10 | PPT and ERP | ASC | FM reduced P300 amplitude, correlated well with PPT |
Ernberg and colleagues [109] | 2003 | 18 | n/a | PP: over masseter | ASC | No difference (trend toward decreased PPT after antagonist) |
Carli and colleagues [110] | 2002 | 145 (FM, CFS, WP, MPTE, MP) | 22 | PPT: CP and TP, HPT, CPT, cold pressor test, ischemic tourniquet test | ASC | FM with decreased PPT (CFS, MPTE), HPT (CFS), cold pressor test (CFS), ischemic tourniquet test (CFS, MPTE, WP, MP) than HC |
Hedenberg-Magnusson and colleagues [111] | 2002 | 18 | 15 masseter myalgia | PPT: over masseter | ASC | Decreased PPT after treatment in both groups. Correlated with symptoms |
Ernberg and colleagues [112] | 2000 | 12 | 12 HC, 12 RA | PPT: masseter | ASC | FM with decreased PPT |
Graven-Nielsen and colleagues [113] | 2000 | 15 FM ketamine Responders | Placebo | EPT, PPT: TA muscle, PPT and pain tolerance: 3 TPs | ASC | Increased PPT at TA muscle, pain pressure tolerance after ketamine compared with placebo. Noted improvement in symptoms |
Ernberg and colleagues [114] | 2000 | 12 | 12 | PPT | ASC | FM with no significant increase in pain or decrease in PPT. HC with increased pain and decrease in PPT after infusion |
Ernberg and colleagues [115] | 1999 | 18 | 10 HC, 17 local myalgia | PPT, pain tolerance: Masseter | ASC | FM with decreased PPT associated with higher fraction of masseter to serum serotonin levels |
Kosek and Hansson [30] | 1997 | 10 | 10 | PPT | ASC | FM decreased PPT |
Kosek and colleagues [31] | 1996 | 10 | 10 | PPT | ASC | FM decreased PPT |
McDermid and colleagues [116] | 1996 | 20 | 20 HC, 20 RA | PPT: TP and CP | ASC | FM decreased PT compared with RA, HC. RA decreased PT compared with HC |
Kosek and colleagues [117] | 1995 | 16 | n/a | PPT at cream site | ASC | No difference in PPT after EMLA cream |
Tunks and colleagues [118] | 1995 1995 | 6 | 6 myofascial 6 pain controls, 6 HC | PPT: TP and CP | ASC | FM and myofascial pain was discriminated from HC by dolorimetry and palpation |
Wolfe and colleagues [119] | 1995 | 391 | n/a | TPC, dolorimetry | ASC | PPT and TPC correlate with symptoms, but TPC correlates better |
Gibson and colleagues [29] | 1994 | 10 | 10 | PPT: TP and CP | ASC | FM decreased PPT at CT and TP, but data not clearly shown |
Lautenbacher and colleagues [120] | 1994 | 26 | 26 | PPT: CP and TP | ASC | FM decreased PPT |
Granges and Littlejohn [121] | 1993 | 60 | 60 | PPT: TP and CP | ASC | FM decreased HPT, PPT, CPT in CP and TP |
Lautenschlager and colleagues [122] | 1991 | 47 | n/a | PPT: TP and CP | ASC | Body diagram correlated better with dolorimetric findings than visual analog scale |