From: Biology and therapy of fibromyalgia. Evidence-based biomarkers for fibromyalgia syndrome
Reference | Year of study | Number of FM patients | Number of Control individuals | Evoked potential | Paradigm | EP evaluated | Findings |
---|---|---|---|---|---|---|---|
Alanoglu and colleagues [46] | 2005 | 34 | 22 | Auditory | Auditory discriminated task paradigm | P300 wave | FM reduced P300 amplitude and prolonged latency. No correlation between EP findings, pain scores, and quality of life measurements |
Yoldas and colleagues [47] | 2003 | 11 | 10 | Auditory | Auditory discriminated task paradigm | P300 wave | FM reduced P300 amplitude, but no difference in potential latency. P300 latency negatively correlated with total myalgic scores and the control point scores. P300 amplitude correlated with PPT and total myalgic scores. No correlation in amplitude or latency with depression or anxiety. |
Ozgocmen and colleagues [48] | 2003 | 13 | 10 | Auditory | Auditory discriminated task paradigm ~before and after sertraline treatment (8 weeks) | P300 wave | no difference in potential latency at baseline. Sertraline treatment resulted in increase in potential amplitude by 8 weeks without change in latency. No correlation between EP findings, fatigue and pain scores, but correlated to total myalgic scores |