Increased susceptibility to collagen-induced arthritis in female mice carrying congenic Cia40/Pregq2fragments

Table 4 Summary of possible candidate genes on chromosome 11 for Cia40/Pregq2

Gene	Position, mb	Description	Reproductive or inflammatory phenotypes of mutation
Ngfr	95.430132 – 95.449049	Nerve growth factor receptor	Perinatal lethality
Phb	95.5528271 – 95.542087	Prohibitin	Lethality before weaning
Igf2bp1	95.818477 – 95.867254	Insulin-like growth factor 2	Fetal growth
Med24	96.565905 – 98.590749	Mediator complex subunit 24	Pups die prior to birth
Gsdm3	98.490658 – 98.499540	Gasdermin	Abnormal loss of skin and hair
Etv4	101.631061 – 101.646685	Ets variant gene 4 (E1A enhancer-binding protein, E1AF)	Mammary gland abnormality, male infertility
Cd79b ^a	106.172655 – 106.176076	CD79B antigen	Hematopoietic, immune
Prkar1a	109.510719 – 109.530970	Protein kinase, cAMP-dependent regulatory, type I, alpha	Embryonic lethality
Abca8a ^a	109.886948 – 109.957292	ATP-binding cassette, sub-family A (ABC1), member 8a	Not known
Map2k6 ^a	110.260436 – 110.386836	Mitogen-activated protein kinase kinase 6	Abnormal immune system
Sox9	112.643538 – 112.649074	SRY-box containing gene 9	Perinatal lethality, cartilage formation, sex reversal

^aPolymorfism between inbreed strains of NMRI and C57BL/10 according to gscan, Wellcome Trust Centre for Human Genetics [13]. Mb for the genes/markers are according to Mouse Ensemble built 36 [18].

ISSN: 1478-6362