Collagen-specific T-cell repertoire in blood and synovial fluid varies with disease activity in early rheumatoid arthritis

Table 5 BV-BJ CDR3 rearrangements expanded after huCollp261–273 stimulation in healthy control DR4⁺ relatives of RA patients

1–2.6^a
BV-BJ^a	MF (VR)^b 04–13 04–14	SR (ST)^b 04–04 01–04	ML (MS)^b 04–07	BI (BC)^{b, c} 04–04 01–04 04–09	GG (BC)^{b, c} 04–08
125,134
other			137 ^d	128, 131, 137^d
6b2-2.6 ^a
209, 215, 218			215
other		212 ^(d)	212 ^d		212 ^d
7-1.6	142	127			139
11-2.2 ^a				135, 138
135, 138
other		141	132		129
13b-2.3 ^a
193, 199, 201					193
other		196
19-2.5	101 ^d		95	104, 110^e	101 ^d , 110 ^e
16-1.6 ^a			83		83, 86
83, 86
other				89, 101	92
16-2.5 ^a
83, 89					83
other				77, 93^e, 96	93 ^e
Ratio: RA shared TCRs/total specific TCRs	0/2	0/4	2/6	2/12	4/11

^aBV-BJ rearrangements that are shared among RA patients are in bold. ^bInitials of the name of the relative of the RA patient is given in brackets. Beneath each patient's initial the HLA DRB1 allele combination(s) are given, as established by PCR using sequence-specific oligonucleotides (see Materials and methods). ^cBI and GG are both related to BC (see Table 6) and are third-degree relatives of each other. ^dhuCollp261–273 specific TCR-β rearrangements shared among healthy individuals. ^ehuCollp261–273 specific TCR-β rearrangements shared only by the two related individuals BI and GG. huCollp261–273, human collagen peptide 261–273; RA, rheumatoid arthritis; TCR, T-cell receptor.

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