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Table 2 CIA severity in Eae39 congenic mice

From: Dissection of a locus on mouse chromosome 5 reveals arthritis promoting and inhibitory genes

  

AUC (d50-73)a

Marker

Mbpb

a/ac (n)

a/b (n)

b/b (n)

p-valued

D5Mit113

77.68

126 ± 41 (14)

87 ± 35 (12)

30 ± 15 (42)

0.0006

D5Mit157

101.06

118 ± 39 (15)

41 ± 17 (27)

46 ± 24 (26)

0.0071

D5Mit240

109.52

118 ± 39 (15)

33 ± 16 (27)

55 ± 25 (26)

0.0075

D5Mit136

119.18

118 ± 39 (15)

4 ± 4 (19)

66 ± 22 (34)

0.0023

D5Mit367

120.31

111 ± 37 (16)

5 ± 4 (17)

66 ± 22 (34)

0.0077

D5Mit137

123.73

107 ± 44 (13)

21 ± 13 (22)

68 ± 22 (33)

0.1014

D5Mit95

125.31

99 ± 41 (14)

22 ± 14 (21)

68 ± 22 (33)

0.1799

D5Mit161

127.40

106 ± 44 (13)

24 ± 14 (35)

64 ± 21 (20)

0.2488

D5Mit59

128.20

99 ± 41 (14)

25 ± 15 (19)

66 ± 22 (34)

0.2322

D5Mit31

139.00

125 ± 50 (11)

47 ± 34 (8)

48 ± 16 (49)

0.0423

  1. aArea under curve (AUC) is the mean ± standard error of the total sum of scores for mice with the respective genotypes (day 50 until day 73). All mice in Figures 1 and 3 (a to l), and littermate controls (b/b) are included in the calculations. The sub-interval congenic mice were generated by intercrossing the C1 congenic mice (Figures 1 and 2).
  2. bMbp = mega base pairs. The Mbp position is according to Ensembl release 49.
  3. ca/a = homozygous RIIIS/J alleles; b/b = homozygous B10.RIII alleles; a/b = heterozygous.
  4. dStatistics calculated with Kruskal-Wallis test.
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Arthritis Research & Therapy

ISSN: 1478-6362

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