Table 2 Sensitivity and specificity of anti-topoisomerase I antibodies

Diffuse systemic sclerosis^a

96

58 (60.4%)

57 (59.4)

Limited systemic sclerosis^a

113

7 (6.2%)

6 (5.3%)

Systemic sclerosis sine scleroderma^a

4

1 (25%)

1 (25%)

Overlap^a

38

1 (2.6%)

1 (2.6%)

Mixed connective tissue disease^a

13

0

0

Undifferentiated connective tissue disease^a

16

0

0

   Sensitivity^a

280

67 (23.9%)

65 (23.2%)

Myositis^b

26

0 (100%)

0 (100%)

Systemic lupus erythematosus^b

208

0 (100%)

0 (100%)

Sjögren's syndrome^b

88

0 (100%)

0 (100%)

Rheumatoid arthritis^b

165

2 (98.8%)

1 (99.4%)

   Specificity^b

487

2 (99.6%)

1 (99.8%)