MICA-210 | MICA-250 | MICA-300 | |||||
---|---|---|---|---|---|---|---|
(a) French population 1 – all individuals without controlling for LD with HLA-DRB1 | |||||||
Minor allele | 4 | 5 | 5.1 | 6 | 9 | A | A |
Frequency in cases/controlsa | 7%/12% | 12%/7% | 42%/36% | 26%/25% | 13%/20% | 23%/34% | 8%/4% |
Minor allele transmitted/untransmitted | 13/21 | 21/13 | 44/36 | 35/33 | 17/29 | 26/48 | 15/7 |
Transmission rate | 38% | 62% | 55% | 51% | 37% | 35% | 68% |
TDT P value | 0.172 | 0.172 | 0.376 | 0.815 | 0.080 | 0.011 | 0.091 |
(b) French population 1, subgroup without HLA-DRB1 risk alleles | |||||||
Minor allele transmitted/untransmitted | 5/10 | 5/4 | 18/15 | 18/12 | 5/10 | 6/18 | 3/1 |
Transmission rate | 33% | 56% | 55% | 60% | 33% | 25% | 75% |
TDT P value | 0.200 | 0.740 | 0.600 | 0.270 | 0.200 | 0.014 | 0.317 |
(c) French population 1, all individuals, controlling for LD with HLA-DRB1 by conditional logistic regression | |||||||
OR (95% CI)b | 0.59 (0.25–1.34) | 1.48 (0.64–3.54) | 1.28 (0.77–2.16) | 1.23 (0.71–2.17) | 0.51 (0.24–1.05) | 0.46 (0.25–0.82) | 1.2 (0.37–4.15) |
P value | 0.235 | 0.428 | 0.379 | 0.518 | 0.072 | 0.007d | 0.944 |
LRTc P value | 0.165 | 0.319 | 0.314 | 0.433 | 0.048 | 0.005d | 0.728 |