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Figure 8 | Arthritis Research & Therapy

Figure 8

From: The Ras guanine nucleotide exchange factor RasGRF1 promotes matrix metalloproteinase-3 production in rheumatoid arthritis synovial tissue

Figure 8

Double immunofluorescence labeling of RasGRF1, MMP-1 and MMP-3 in rheumatoid arthritis synovial tissue. Rheumatoid arthritis synovial tissue was stained with combinations of anti-Ras guanine nucleotide-releasing factor 1 (anti-RasGRF1) and either anti-matrix metalloproteinase (MMP)-1 (upper panels) or anti-MMP-3 (lower panels). Sections were then stained with fluorochrome-conjugated anti-rabbit immunoglobulin (red) and anti-mouse IgG (green) antibodies to visualize RasGRF1 and MMP expression, respectively. Colocalization of RasGRF1 with MMPs is visualized by yellow staining in merged images (right panels).

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Arthritis Research & Therapy

ISSN: 1478-6362

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