Lessons from animal models of arthritis over the past decade

Table 1 Models of arthritis

Model	Abbreviation	Species^a	Feature	IC	T cell	References
Trigger-induced models
Non-specific immune stimuli
Adjuvant-induced arthritis	AA	Lewis rat	Autoimmune	-	+	[1, 2]
Oil-induced arthritis	OIA	DA rat	Autoimmune	-	+	[3]
Pristane-induced arthritis	PIA	DA rat	Autoimmune	-	+	[4, 5]
Cartilage directed autoimmunity
Collagen-induced arthritis	CIA	DBA mouse	CII AI	+	+	[6, 7]
Proteoglycan-induced arthritis	PGIA	Balb/c mouse	PG AI	+	+	[8, 9]
Infectious agents/exogenous triggers
Streptococcal cell wall arthritis	SCW-A	Lewis rat	Persistent bacteria AI	-	+	[10]
Flare	SCW-F	Mouse	Th17	-	+	[11]
Antigen-induced arthritis	AIA	Rabbit, mouse	Persistent antigen	+	+	[12, 13]
Flare	AIA-F	Mouse	Th17	-	+	[14]
Transgenic spontaneous models
HTLV-induced arthritis	HTLV	Mouse	Viral tax antigen	-	+	[15]
KRN arthritis	KRN	K/BxN mouse	GPI AI	+	+	[16, 17]
SKG arthritis	SKG	Mouse	ZAP-70 T cell defect	-	+	[18, 19]
GP130 arthritis	GP130	Mouse	STAT3, T cell defect	-	+	[20, 21]
TNF transgenic arthritis	TNFtg	Mouse	TNF overexpression	-	-	[47, 48]
IL-1ra transgenic arthritis	IL-1ra-/-	Balb/c mouse	Autoimmune T cells	±	+	[23]
IL-1 transgenic arthritis	IL-1tg	Mouse	IL-1 overexpression	-	-	[22]
Immune complex models
Collagen type II	CAIA	DBA mouse	Mouse CII antibody	+	-	[26, 27]
KRN serum	GPI	Balb/c mouse	Mouse GPI antibody	+	-	[31]
Poly-L-lysine-lysozyme	PLL-L	DBA mouse	Cationic antigen	+	-	[28]

^aMost commonly used. AI = autoimmune; CAIA = collagen antibody-induced arthritis; GPI = glucose-6-phosphate isomerase; IC = immune complexes as an early feature; PG = proteoglycan.

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