| Healthy controls (n = 216) | Scleroderma patients (n = 444) | Pvalue | |||
---|---|---|---|---|---|---|
 | pg/ml | log n cytokine | pg/ml | log n cytokine | Unpaired ttest | Adjusted for age and gender |
TNFα | 8.9 ± 0.5 | 1.90 ± 0.06 | 14.1 ± 0.7 | 2.27 ± 0.05 | <0.0001 | <0.0001 |
IL1β | 7.0 ± 1.2 | 0.36 ± 0.11 | 5.8 ± 0.8 | 0.38 ± 0.07 | NS | NS |
IL-6 | 5.2 ± 0.8 | 0.55 ± 0.11 | 9.7 ± 1.2 | 1.24 ± 0.07 | <0.0001 | <0.0001 |
IL-8 | 77.7 ± 20.1 | 1.32 ± 0.15 | 84.3 ± 13.8 | 1.58 ± 0.11 | NS | NS |
IL-2 | 2.8 ± 0.7 | 0.05 ± 0.08 | 2.4 ± 0.4 | 0.02 ± 0.05 | NS | NS |
IFNγ | 2.9 ± 0.5 | - 0.17 ± 0.08 | 8.2 ± 4.6 | - 0.06 ± 0.06 | NS | 0.05 |
IL-12p70 | 16.2 ± 4.3 | 0.66 ± 0.12 | 53.2 ± 12.8 | 0.71 ± 0.09 | NS | NS |
IL-4 | 5.1 ± 0.8 | 0.38 ± 0.11 | 5.4 ± 1.2 | 0.32 ± 0.07 | NS | NS |
IL-5 | 1.2 ± 0.2 | - 0.27 ± 0.05 | 11.1 ± 5.1 | - 0.14 ± 0.06 | NS | NS |
IL-13 | 24.6 ± 1.7 | 2.97 ± 0.06 | 51.5 ± 12.0 | 3.12 ± 0.05 | 0.05 | NS |
IL-10 | 18.5 ± 11.6 | 0.62 ± 0.10 | 30.6 ± 10.0 | 0.83 ± 0.08 | NS | 0.07 |
IL-17 | 1.9 ± 0.2 | 0.04 ± 0.08 | 1.2 ± 0.1 | - 0.22 ± 0.04 | 0.0009 | 0.0005 |
IL-23 | 4.7 ± 1.1 | 0.46 ± 0.12 | 3.7 ± 0.5 | 0.18 ± 0.07 | 0.04 | 0.014 |