Figure 4

Degree of tissue inflammation and bone and cartilage destruction in the absence of endogenous Th1 and Th2 cytokines. (a and b) Tissue sections of arthritic hind paw from mice that received neutralizing antibodies to IFN-γ alone, IFN-γ + IL-4, IL-4 alone, rat IgG or no antibody were stained with hematoxylin and eosin. The sections were scored for inflammatory infiltrate, synovitis, bone damage and cartilage destruction. Data are presented as mean +/- standard deviation (SD). * P < 0.05.