Functional consequences of DECTIN-1early stop codon polymorphism Y238X in rheumatoid arthritis

Table 3 Between-group differences for DECTIN-1 Y238X genotype in joint-damage progression

Parameter	Estimate	SE	Pvalue
Intercept	3.32	0.32	< 0.0001
DECTIN-1 genotype	0.05	0.79	0.95
Intercept	1.07	0.58	0.065
DECTIN-1 genotype	-0.40	0.71	0.57
Joint damage at baseline	2.65	0.53	< 0.0001
Rheumatoid factor +	1.28	0.63	0.043
Average DAS28^a	1.26	0.24	< 0.0001

DAS28: Disease Activity Score using 28 joint counts. Results of the linear regression model with 262 RA patients. The upper model tests the difference in annual joint-damage progression rate between wild-type patients and patients heterozygous for the DECTIN-1 Y238X polymorphism, indicated by the estimate of DECTIN-1 genotype (P = 0.95). The lower model tests the same (P = 0.57), with addition of baseline joint damage, rheumatoid factor positivity, and the time-averaged DAS28 as confounders. ^aTime-averaged DAS28 was centered.

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