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Figure 5 | Arthritis Research & Therapy

Figure 5

From: Urokinase-type plasminogen activator and arthritis progression: role in systemic disease with immune complex involvement

Figure 5

Urokinase-type plasminogen activator gene-deficient mice are resistant to T-cell-independent arthritis models. (a) Type II collagen mAb-induced arthritis (CAIA) using Pam-3-Cys as a boost. C57 (n = 10), u-PA-/- (n = 7) mice. P < 0.05, u-PA-/- vs. C57 mice. (b) K/BxN serum transfer model. C57 (n = 7), u-PA-/- (n = 5) mice. P < 0.0001, u-PA-/- vs. C57 mice. (c) Histologic pictures of representative joints from C57BL/6 and u-PA-/- mice with K/BxN serum transfer arthritis. H & E, Safranin O fast green and fibrin(ogen) staining is shown. (d) Quantification of histologic features. P < 0.05, u-PA-/- vs. C57 mice for each histologic feature. Values expressed as mean ± standard error of the mean.

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Arthritis Research & Therapy

ISSN: 1478-6362

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