Table 4 Association of HLA-DRB1 alleles with the SE, HLA-DR3, and DERAA motif with ACPA+ or ACPA- rheumatoid arthritis
Controls (n = 269) | Rheumatoid arthritis patients (n = 231) | |||||||
|---|---|---|---|---|---|---|---|---|
ACPA+(n = 143) | ACPA-(n = 88) | |||||||
P value | OR, 95% CI | P value | OR, 95% CI | |||||
SE | Absence, n (%) | 157 (58.4) | 46 (32.2) | 0.0001 | 2.95, 1.93-4.53 | 57 (64.8) | 0.31 | 0.76, 0.46-1.27 |
Presence, n (%) | 112 (41.6) | 97 (67.8) | 31 (35.2) | |||||
DR3 | Absence, n (%) | 216 (80.3) | 125 (87.4) | 0.07 | 0.58, 0.32-1.04 | 63 (71.6) | 0.10 | 1.61, 0.93-2.80 |
Presence, n (%) | 53 (19.7) | 18 (12.6) | 25 (28.4) | |||||
DERAA | Absence, n (%) | 197 (73.2) | 118 (82.5) | 0.03 | 0.58, 0.34-0.64 | 58 (65.9) | 0.22 | 1.41, 0.84-2.37 |
Presence, n (%) | 72 (26.8) | 25 (17.5) | 30 (34.1) | |||||