Figure 2

Augmentation by 2GF of FLS secretion of particular cytokines, chemokines and MMPs induced by TNFα. FLS were cultured for 24 hours with TNFα and growth factors as in Figure 1, and supernatants analyzed by ELISA (MMPs) or Luminex multiplex bead assay (all others). Mean & SEM, n = 3 to 6 RA FLS lines. Asterisk indicates P < 0.05 to TNFα alone and 2GF alone, and ampersand indicates P < 0.05 to TNFα alone, by ANOVA/Tukey-Kramer's.