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Table 1 Baseline characteristics of the patients with comparison between patients with/without persistent arthritis at one year

From: The likelihood of persistent arthritis increases with the level of anti-citrullinated peptide antibody and immunoglobulin M rheumatoid factor: a longitudinal study of 376 patients with very early undifferentiated arthritis

 

All patients

(n = 376)

Persistent disease

(N = 174)

Self-limiting disease

(N = 202)

P*

  

Persistent synovitis

(with or without DMARD)

(N = 122)

DMARD prescribed

(without persistent synovitis)$

(N = 52)

  

Female gendera

218 (58.0)

78 (63.9)

32 (61.5)

108 (53.5)

0.06

Age, yearsb

46.3 (14.8)

49.0 (14.9)

45.6 (17.1)

44.9 (14.0)

0.04

Arthritis duration, daysc

32 (10 to 64)

50 (21 to 69)

59 (27 to 76)

21 (7 to 49)

<0.001

SJC (0 to 68)c

2 (1 to 5)

4 (1 to 9)

4 (2 to 8)

1 (1 to 3)

<0.001

TJC (0 to 28)c

1 (1 to 3)

2 (1 to 6)

2 (1 to 5)

1(0 to 2)

<0.001

ESR, mm/hc

24 (11 to 46)

27 (10 to 50)

32 (17 to 51)

19 (10 to 38)

0.005

CRP, mg/lc

15.0 (5.0 to 36.4)

15 (5 to 35)

18 (9 to 45)

14.0 (3.5 to 36.2)

0.16

IgM RF level, units/mlc

4 (1 to 10)

6 (2 to 40)

6 (2 to 30)

3 (1 to 7)

<0.001

IgM RF positivea

59 (15.7)

36 (29.5)

13 (25.0)

10 (5.0)

<0.001

Anti-CCP2 level, units/mlc

3 (2 to 6)

4 (2 to 83)

4 (2 to 25)

2 (2 to 4)

<0.001

Anti-CCP2 positivea

62 (16.5)

39 (32.0)

13 (25.0)

10 (5.0)

<0.001

Assessor's global VAS, mmb

35.8 (20.7)

39.5 (21.8)

44.7 (23.0)

31.3 (18.2)

<0.001

Patient's global VAS, mmb

53.8 (24.0)

57.4 (21.9)

59.5 (26.1)

50.2 (24.1)

0.001

Small joint arthritisa

173 (46.0)

73 (59.8)

33 (63.5)

67 (33.2)

<0.001

Morning stiffness>1 houra

195 (51.9)§

70 (57.9)

31 (60.8)

101 (58.0)

0.04

DAS28b

4.05 (1.32)

4.47 (1.35)

4.61 (1.36)

3.65 (1.15)

<0.001

HAQ (0-3)b

0.89 (0.67)

0.98 (0.64)

1.07 (0.80)

0.78 (0.63)

0.001

Monoarthritisa

154 (41.0)

37 (30.3)

12 (23.1)

105 (52.0)

<0.001

   -of the kneea

80 (51.9)

20 (54.1)

6 (50.0)

54 (51.4)

0.85

Fulfilment of 1987 ACR criteriaa†

70 (18.6)

37 (30.3)

16 (30.8)

17 (8.4)

<0.001

  1. ACR: American College of Rheumatology; anti-CCP2: 2nd generation anti-citrullinated peptide antibody; CRP: C-reactive protein; DAS: Disease Activity Score; ESR: erythrocyte sedimentation rate; HAQ: Health Assessment Questionnaire; RF: rheumatoid factor; SJC: swollen joint count; TJC: tender joint count; VAS: visual analogue scale; small joint arthritis, joint swelling in PIP-, MCP- or MTP joint(s).
  2. $No statistical differences between the persistent arthritis group and DMARD group for any of the baseline variables were found.
  3. *Comparing persistent disease group with self-limiting disease group.aCount (%).bMean (standard deviation).cMedian (inter-quartile range).§N = 369.Modified from the 1987 ARA criteria according to available data (excluding criteria on erosive disease and duration of symptoms).