Figure 1

The altered expression profile of miRNAs in CD4⁺ T cells from SF of RA patients. (a) Compared with normal CD4⁺ T cells, altered expression of 16 microRNAs (miRNAs) with fold change (>2) was found in CD4⁺ T cells of rheumatoid arthritis (RA) by miRNA microarray analysis. (red: upregulation; green: downregulation) (b) Expression of eight miRNAs was altered in both RA patients by miRNA microarray analysis. Six of them were upregulated and two of them were downregulated. (c) Compared with healthy controls, levels of miRNAs - miR-498, miR-363, miR-146a, miR-150, miR-512-5P, miR-345-MM1, miR-146b and miR-129 - expression in peripheral blood (PB; n = 20) and synovial fluid (SF; n = 22) of RA patients and PB (n = 12) of healthy controls were determined by Taqman quantitative RT-PCR analysis. Horizontal bars represent the mean values. Ctl-PB: CD4⁺ T cells from PB of healthy controls; RA-PB: CD4⁺ T cells from PB of RA patients; RA-SF: CD4⁺ T cells from SF of RA patients. **P < 0.01, *P < 0.05.