Accelerated hand bone mineral density loss is associated with progressive joint damage in hands and feet in recent-onset rheumatoid arthritis

Table 3 Baseline and one-year follow-up predictors of subsequent progressive total joint damage in hands and feet after four years derived from multivariate logistic regression analysis

	Progressive total joint damage 1-4 ≥ 5 units
	β	OR (95% CI)	Pvalue
Baseline variables
Presence ACPA	1.20	3.14 (1.37-6.12)	0.015
Presence RF	0.59	1.80 (0.55-6.08)	0.314
SHS ≥ 1 unit	0.85	2.55 (0.48-13.0)	0.342
First year follow-up variables
High AUC ESR	0.001	1.001 (0.998-1.004)	0.444
High AUC CRP	0.001	1.001 (0.999-1.004)	0.339
Progressive SHS ≥ 5 units	3.35	27.1 (10.9-67.4)	0.000
Hand BMD loss >0.003 g/cm²	0.30	1.30 (0.38-3.84)	0.688
R², adjusted		0.534

All variables with a P < 0.10 in the univariate analyses were entered in this multivariate analysis corrected for age, gender, postmenopausal status, BMI and health assessment questionnaire and first year follow-up variables additionally corrected for the use of anti-resorptive therapy (bisphosphonates, calcium and vitamin D suppletion and hormone replacement therapy) and intraarticular corticosteroid injections during first year and treatment group during.
ACPA, anti-citrullinated protein antibodies; AUC, area under the curve; BMD, bone mineral density; BMI, body mass index; CI, confidence interval; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; OR, odds ratio; RF, rheumatoid factor; SHS, Sharp-van der Heijde score.

ISSN: 1478-6362