Rare incidence of methotrexate-specific lesions in liver biopsy of patients with arthritis and elevated liver enzymes

Table 2 Distribution of the histological liver lesions depending on the associated rheumatic disease

	AIH-like lesions	NASH-like lesions	Limited liver lesions	PBC	Direct MTX toxicity	Total
Rheumatoid arthritis	13 (31.7%)	9 (22%)	1 (2.4%)	1 (2.4%)	1 (2.4%)	25 (61%)
Spondylarthropathy	2 (4.9%)	3 (7.3%)	2 (4.9%)	0 (0%)	1 (2.4%)	8 (19.5%)
Primary Sjögren syndrome	0 (0%)	1 (2.4%)	4 (9.8%)	1 (2.4%)	0 (0%)	6 (14.6%)
Connective tissue disease	2 (4.9%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	2 (4.9%)
	17 (41.5%)	13 (31.7%)	7 (17%)	2 (4.9%)	2 (4.9%)	41 (100%)

Data presented as n (%). AIH, autoimmune hepatitis; MTX, methotrexate; NASH, nonalcoholic steatohepatitis; PBC, primary biliary cirrhosis.

ISSN: 1478-6362