Atherosclerosis in early rheumatoid arthritis: very early endothelial activation and rapid progression of intima media thickness

Table 5 Simple linear regression models of associations between endothelial biomarkers and sex, age, blood pressure or DAS28 in 79 patients with early RA

	Sex (female)		Age		Systolic BP		DAS28
	β	P	β	P	β	P	β	P
PAI-1	-22.1/+	0.034	0.84/year	0.033	0.58/mmHg	0.045^†	6.40/unit	0.048^†
tPA-mass	-2.2/+	0.008	0.11/year	0.001	0.064/mmHg	0.008^†	0.50/unit	0.045^†
VWF		ns	3.36/year	<0.001	1.53/mmHg	0.012^†		ns
sVCAM-1		ns		ns		ns	-48.1/unit	0.020
sICAM-1		ns	2.76/year	0.048		ns		ns
sE-selectin		ns		ns		ns	2.99/unit	0.073
sL-selectin	267.2/+	0.002	-14.4/year	<0.001	-6.9/mmHg	0.008^†	-63.8/unit	0.001
MCP-1		ns	21.3/year	0.031	15.5/mmHg	0.046^†		ns

^†Not significant after adjustment for sex and/or age.
BP, blood pressure; DAS28, disease activity score; MCP-1, monocyte chemotactic protein-1; ns, not significant; PAI-1, plasminogen activator inhibitor-1; RA, rheumatoid arthritis; sICAM-1, soluble intercellular adhesion molecule-1; sVCAM-1, soluble vascular cell adhesion molecule-1; tPA, tissue plasminogen activator; VWF, VonWillebrand factor.

ISSN: 1478-6362