Applying science in practice: the optimization of biological therapy in rheumatoid arthritis

Table 1 Remission criteria

Criteria	Components/Formula	Cut-offs
ARA [19] and modified	No fatigue (used only for ARA, not for modified ARA criteria)	5/6 for ARA criteria and 4/5 for modified
ARA [20, 21]	No joint pain by history	ARA; 2 months required
	No joint tenderness or pain on motion
	No soft tissue swelling in joints or tendon sheaths
	Morning stiffness for not more than 15 minutes
	ESR of less than 30 mm/hour in women and less than 20 mm/hour in men
DAS [20]	[0.54 × √(Ritchie)] + [0.065 × SJC44] + [0.33 × ln (ESR)] + [0.0072 × GH (mm)]	Less than 1.6
DAS28 [21]	[0.56 × √(TJC28)] + [0.28 × √(SJC28)] + [0.70 × ln (ESR)] + [0.014 × GH (mm)]	Less than 2.6 (less than 2.4 also proposed) [28]
SDAI [28]	SJC28 + TJC28 + PGA (cm) + EGA (cm) + CRP (mg/dL)	Not more than 3.3
CDAI [54]	SJC 28 + TJC28 + PGA (cm) + EGA (cm)	Not more than 2.8

ARA, American Rheumatism Association; CDAI, clinical disease activity index; CRP, C-reactive protein; DAS, disease activity score; DAS28, disease activity score with 28-joint assessment; EGA, evaluator global assessment of disease activity; ESR, erythrocyte sedimentation rate; GH, global health by visual analogue scale; ln, natural logarithm; PGA, patient global assessment of disease activity; Ritchie, Ritchie articular index; SDAI, simplified disease activity index; SJC28, 28 swollen joint count; SJC44, 44 swollen joint count; TJC28, 28 tender joint count.

ISSN: 1478-6362