Figure 3

u-PA^-/- mice show sustained proteoglycan loss in their knee joints following antigen-induced arthritis induction. Mice were sacrificed at 0, 1, 2, and 6 weeks after intra-articular (i.a.) injection. (a) Representative proteoglycan staining (safranin O). (b) Quantification of proteoglycan loss. Results are expressed as the mean ± standard error of the mean (five mice per group). *P = 0.008, C57BL/6 versus u-PA^-/- mice; P = 0.015, C57BL/6 over time. mBSA, methylated bovine serum albumin; u-PA^-/-, urokinase-type plasminogen activator gene-deficient.