Urokinase-type plasminogen activator and arthritis progression: contrasting roles in systemic and monoarticular arthritis models

Table 1 Comparison of arthritis development in u-PA^-/- mice in different arthritis models

	Polyarticular u-PA is deleterious^a	Monoarticular u-PA is protective^b
Induction	Systemic (intra-dermal, intravenous, and intraperitoneal)	Intra-articular
Models	CIA [3, 5], CAIA [4], and K/BxN serum transfer [4]	mBSA/IL-1 [7] and AIA [6]
Mechanism of arthritis development	Immune complex-mediated and complement-dependent	Local trauma, increased fibrin deposition, and 'wound healing-like' process

^au-PA is deleterious; that is, disease was reduced in u-PA^-/- mice. ^bu-PA is protective; that is, disease was worse in u-PA^-/- mice. AIA, antigen induced arthritis; CAIA, type II collagen monoclonal antibody-induced arthritis; CIA, collagen-induced arthritis; mBSA, methylated bovine serum albumin; u-PA, urokinase-type plasminogen activator; u-PA^-/-, urokinase-type plasminogen activator gene-deficient.

ISSN: 1478-6362