Collagen-induced arthritis in common marmosets: a new nonhuman primate model for chronic arthritis

Table 2 Integrated Discomfort Score

Disease score	Characteristics	Monitoring	Maximal duration^a
0	Asymptomatic	Daily	End of experiment
	No general discomfort signs
0.5	Fever ( > 0.5°C)	Twice per week	12 weeks
1	Apathy	Daily	10 weeks
	Less mobility but no pain	Daily
	Loss of appetite	Daily
2	Weight loss	Twice per week	6 weeks
	Warm extremities	Twice per week
	Treatable pain without STS	Daily
3	Moderate redness + STS of joints	Twice per week	4 weeks
	Normal flexibility of extremities	Twice per week
4	Severe redness + STS of joints	Twice per week	2 weeks
	With joint stiffness
5	Serious lethargy	Daily	18 hours
	Serious untreatable pain	Daily	18 hours
	Serious immobility of joints	Twice per week	18 hours^b
	Body weight loss >25%	Twice per week	18 hours^b

STS, soft tissue swelling. ^aThe discomfort time combination is used in a cumulative fashion. ^bCan only be assessed in the sedated monkey, which cannot be done more than twice per week for ethical reasons.

ISSN: 1478-6362