Figure 2From: Toll-like receptor 3 upregulation by type I interferon in healthy and scleroderma dermal fibroblastsComparison of TLR3 upregulation by IFNα in healthy control and systemic sclerosis (SSc), or scleroderma, dermal fibroblasts. (A) Dermal fibroblasts were stimulated for 24 hours with 50 ng/mL IFNα, and TLR3 was determined by performing qRT-PCR assays. The magnitude of induction of TLR3 expression by IFNα was significantly greater in dermal fibroblasts from patients with SSc (n = 11) than in those from healthy controls (n = 25; P = 0.003). (B) SSc dermal fibroblasts have a greater magnitude of upregulation of TLR3 with IFN at concentrations ranging from 1 to 100 ng/mL (n = 4 in each group; *P < 0.05 (Wilcoxon signed-rank test)).Back to article page