Study | Study population (years follow-up) | Number of cases (% women) | Postmenopausal women | CV disease excluded | Mean age | Outcome CV disease | Outcome bone mass | Results # | Quality |
---|---|---|---|---|---|---|---|---|---|
Sennerby, 2009 [13] | Population-based (20) | 31,936 (NA) | NA | Yes | 67.9 to 74.4 | CV disease by National patient registry, ICD 9 codes | Incident hip fracture by National patient registry, ICD 9 codes | Women: HR: 4.42 (95% CI 3.49 to 5.61) Men: HR: 6.65 (95% CI 4.82 to 9.19) | 3 |
Szulc, 2008 [14] | Population-based (10) | 781 (0%) | No | No | 65 | AC by X-spine | Incident fracture by hospital records or X-ray | OR: 2.54 to 3.04 (P < 0.005 to 0.001) | 3 |
Naves, 2008 [4] | Population-based (4) | 624 (51%) | NA | No | 65 | AC by X-spine | BMD lumbar spine and femur by DXA Incident fracture by hospital record or X-ray | Change BMD spine in progression AC vs no progression AC: -1.48% vs 1.43% (P <.0001) Change BMD hip in progression AC and no progression AC: -0.48% vs 0.23% (P = 0.315) Incident fracture: OR: 2.13 (95% CI 0.85 to 5.31) | 3 |
Von Muhlen, 2009 [15] | Population-based (4) | 1,332 (60%) | NA | No | 73.8 | PAD by ABI | BMD lumbar spine and hip by DXA and incident fracture by X-ray | Women: Change BMD in PAD vs no PAD: 59.2% vs 43.5% (P < 0.05) Incident non-vert fracture: OR: 0.84 (95% CI 0.31 to 2.26) Men : Change BMD in PAD vs no PAD : 43.5% vs 35.5% (P = 0.20) Incident non-vert fracture: OR: 1.52 (95% CI 0.30 to 7.45) | 3 |
Collins, 2009 [2] | Population-based (5.4) | 4,302 (0%) | NA | No | 73.5 | PAD by ABI | BMD hip by DXA Incident fractures by x-ray and hospital records | Change BMD in PAD vs no PAD: -0.60% vs -0.32% (P < 0.001 PAD and non-vert fracture risk: HR = 1.47 (95% CI 1.07 to 2.04) | 3 |
Hak, 2000 [3] | Population-based (9) | 236 (100%) | No (100%) | No | 49 | AC by X-spine | MCA by radiogrammetry | MCA in patients with AC progression vs no AC progression -3.5 mm vs -2.0 mm (P < 0.01) | 3 |
Samelson, 2007 [12] | Population-based (21) | 2,499 (58%) | Â | No | 61 | AC by X-spine | Incident hip fracture by hospital records and death certificates | Women: HR: 1.4 (0.8 to 2.3) Men: HR: 1.2 (0.2 to 5.7) | 4 |
Bagger, 2006 [1] | Population-based (7.5) | 2,262 (100%) | Yes (100%) | No | 65 | AC by X-spine | BMD lumbar spine and hip and incident fractures by hospital records or X-ray | Change hip BMD AC score ≥3 vs <3: -0.38% vs -0.25% (P < 0.001) AC and hip fracture: OR: 2.3 (95% CI 1.1 to 4.8) AC and vert fracture: OR: 1.2 (95% CI 1.0 to 1.5) | 4 |
Schulz, 2004 [17] | Clinic-based (8) | 228 (100%) | Yes | No | 65.2 | AC by CT-scan of spine | BMD spine by CT-scan | Change BMD AC vs no AC: -5.3% vs -1.3% (P < 0.001) | 6 |