Table 1 Overview of the skin histology parameters and scoring systema
From: Histopathological cutaneous alterations in systemic sclerosis: a clinicopathological study
Method | Parameter | Scoring system |
|---|---|---|
Histology (H&E) | Epidermal pigmentation | 10-cm VAS |
Histology (MT) | Hyalinised collagen | 10-cm VAS [7] |
IHC (α-SMA) | Myofibroblasts | 10-cm VAS [7] |
Histology (H&E) | Mean epidermal thickness | Semiquantitative |
Histology (H&E) | Mononuclear cellular infiltration | Semiquantitative [14] |
Histology (CI) | Mucin deposition in deep dermis | Semiquantitative [16] |
Histology (H&E) | Calcification | Present or absent |
Histology (MT) | Entrapment of an eccrine sweat gland | Present or absent |
Histology (H&E) | Fibroplasia | Present or absent |
IHC (CD3) | Focal exocytosis | Present or absent |
Histology (H&E) | Loss of adnexae | Present or absent |
Histology (H&E) | Loss of epidermal papillae | Present or absent |
Histology (H&E) | Intima proliferation of deep arterioles | Present or absent |
Histology (H&E) | Parakeratosis | Present or absent |
Histology (H&E) | Pigment incontinence | Present or absent |
Histology (H&E) | Telangiectasia in papillary dermis | Present or absent |