Table 1 Mutational frequency of the nonproductive and productive Vλ repertoires of the patient with systemic lupus erythematosus (SLE) and normal subjects
From: Perturbations in the impact of mutational activity on Vλ genes in systemic lupus erythematosus
Patient with SLE | Normal subjects | |||||
|---|---|---|---|---|---|---|
Nonproductive | Productive | Χ2P < | Nonproductive | Productive | Χ2P < | |
Number of Vλ nucleotides | 16679 | 28496 | 12679 | 39225 | 0.001 | |
Number of Vλ nucleotides in | 13194 | 23819 | 6339 | 21821 | 0.001 | |
mutated rearrangements | ||||||
Number of mutations | 412 | 807 | 76 | 440 | ||
Mutational frequency of all | 2.5 | 2.8 | 0.022 | 0.60 | 1.12 | 0.001 |
VλJλ gene rearrangements (%) | ||||||
Mutational frequency of mutated | 3.1 | 3.4 | NS | 1.19 | 2.02 | 0.001 |
VλJλ gene rearrangements (%) | ||||||