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Table 3 Meta-analysis on the association between HLA- A alleles and BD†

From: Associations between the HLA-Apolymorphism and the clinical manifestations of Behcet's disease

Allele

Total subjects

HLA-B*51 non-carriers

 

OR (95% CI)

P

I2

(%)

P het

Weight

(%)

OR (95% CI)

P

I2

(%)

P het

Weight

(%)

A*01:01

0.54 (0.21 to 1.42)

0.21

76

0.04

92.7

0.65 (0.22 to 1.91)

0.43

60

0.11

92.7

A*02:01

1.20 (0.97 to 1.48)

0.09

0

0.70

65.7

1.13 (0.87 to 1.47)

0.37

0

0.33

70.5

A*02:03

0.96 (0.35 to 2.65)

0.93

27

0.24

67.5

0.99 (0.32 to 3.09)

0.99

0

0.47

70.9

A*02:06

0.86 (0.66 to 1.13)

0.28

0

0.69

58.2

0.73 (0.50 to 1.06)

0.10

0

0.62

60.7

A*02:07

1.96 (1.34 to 2.85)

0.0005

0

0.62

66.6

2.00 (1.30 to 3.09)

0.002

0

0.69

69.7

A*02:10

0.37 (0.06 to 2.37)

0.30

0

0.43

80.0

0.37 (0.05 to 3.05)

0.36

0

0.72

74.5

A*03:01

0.44 (0.15 to 1.26)

0.13

0

0.56

71.1

0.77 (0.26 to 2.21)

0.62

0

0.84

75.7

A*03:02

0.71 (0.12 to 4.21)

0.70

0

0.56

52.4

1.12 (0.18 to 6.77)

0.90

0

0.64

51.9

A*11:01

0.78 (0.60 to 1.03)

0.08

77

0.04

50.5

0.85 (0.61 to 1.19)

0.35

51

0.15

50.6

A*11:02

1.30 (0.30 to 5.57)

0.73

75

0.05

18.0

1.23 (0.20 to 7.71)

0.82

57

0.13

11.5

A*24:02

0.89 (0.75 to 1.05)

0.18

44

0.18

47.0

0.83 (0.67 to 1.03)

0.10

0

0.43

48.8

A*24:20

0.60 (0.13 to 2.83)

0.52

59

0.12

12.1

0.68 (0.12 to 3.73)

0.65

63

0.10

12.6

A*26:01

1.89 (1.41 to 2.53)

<0.0001

0

0.91

38.9

2.42 (1.73 to 3.39)

<0.00001

0

0.62

41.3

A*26:02

1.48 (0.90 to 2.42)

0.12

7

0.30

64.5

1.93 (1.09 to 3.40)

0.02

69

0.07

69.1

A*26:03

2.01 (1.14 to 3.56)

0.02

0

0.51

28.4

2.40 (1.17 to 4.91)

0.02

0

0.70

36.6

A*26:05

3.69 (0.44 to 31.24)

0.23

0

0.69

45.3

NA

    

A*31:01

1.22 (0.91 to 1.62)

0.18

79

0.03

51.9

0.73 (0.45 to 1.19)

0.21

0

0.76

51.8

A*33:03

0.52 (0.39 to 0.70)

<0.00001

64

0.09

71.0

0.58 (0.41 to 0.81)

0.001

67

0.08

71.3

  1. †Genetic data were pooled using allelic frequency.
  2. CI, confidence interval; I2, between-study heterogeneity; NA, not applicable; OR, odds ratios for the risk to develop BD; P, P-values for significance of each HLA-A allele in the pooled genetic effect (calculated by Mantel-Haenszel fixed method); Phet, P values for heterogeneity statistics; weight (%), weight of the present study.