Safety and clinical outcomes of rituximab therapy in patients with different autoimmune diseases: experience from a national registry (GRAID)

Table 1 Patient demographics and mean doses of rituximab received by patients with various autoimmune diseases

Diagnosis	Patients, n (%)	Total observation time, patient-years	Mean (SD) rituximab dose, mg
*Total*	*370*	*299*	*2,440 (1,295)*
Arthritis (non-RA)/ankylosing spondylitis/psoriatic arthritis	6 (1.6)	3.8	2,333 (816)
Autoimmune haemolytic anaemia	3 (0.8)	1.6	2,233 (204)
Autoimmune thrombocytopenia	10 (2.7)	6.5	2,602 (1,047)
Glomerulonephritis	9 (2.4)	7.0	2,150 (1,660)
Cryoglobulinaemic vasculitis	5 (1.4)	4.1	2,576 (971)
Wegener's granulomatosis/microscopic polyangiitis	58 (15.7)	61.4	3,008 (1,524)
Multiple sclerosis/neuromyelitis optica	56 (15.1)	48.3	2,679 (1,252)
Myasthenia gravis	5 (1.4)	2.7	1,890 (1,107)
Pemphigus	37 (10.0)	22.7	1,755 (1,163)
Sjögren's syndrome	6 (1.6)	4.3	2,271 (995)
Polydermatomyositis	26 (7.0)	23.4	2,634 (1,810)
Systemic lupus erythematosus	85 (23.0)	66.8	2,331 (1,033)
Vasculitis	13 (3.5)	9.5	2,277 (1,168)
Overlap syndromes: mixed connective tissue disease	19 (5.1)	16.3	2,550 (1,031)
Others^a	32 (8.6)	20.8	2,079 (1,224)

RA, rheumatoid arthritis; SD, standard deviation.
^aOther autoimmune diseases included: Felty syndrome (n = 1); antiphospholipid syndrome (n = 1); chronic inflammatory demyelinating polyneuropathy (CIDP) (n = 3); anti-myelin associated glycoprotein associated with CIDP (n = 1); anti-Scl70-positive systemic sclerosis with myositis (n = 1); thrombotic thrombocytopenic purpura (n = 2); epidermolysis bullosa acquisita (n = 3); bullous pemphigoid (n = 1); mucous membrane pemphigoid (n = 1); uveitis (n = 1); Behçet disease (n = 1); systemic sclerosis (n = 1); systemic sclerosis with CREST syndrome (n = 1); diffuse cutaneous sclerosis (n = 1); common variable immunodeficiency (n = 1); Castleman's disease (n = 1); human immunodeficiency virus and myopathy (n = 1); Still's disease (n = 1); Crohn's disease (n = 1); Lambert-Eaton myasthenic syndrome (n = 1); autoimmune neuropathy (n = 1); stiff-person syndrome (n = 1); unspecified vasculitis (n = 1); anti-Hu positive encephalopathy of the brain stem (n = 1); acquired factor VIII haemophilia (n = 1); sarcoidosis (n = 1); diagnosis not specified (n = 1).

ISSN: 1478-6362