Table 1 Cytokine-targeting agents and their clinical trials in SLE
Cytokine target | Therapeutic agent | Stage of clinical trial | References |
|---|---|---|---|
IL-6 | Tocilizumab | Phase I | [24] |
TNFα | Infliximab, etanercept | Phase I; phase II and III trials terminated prematurely | |
IFNα | Sifalimumab (MEDI-545), rontalizumab (rhuMab) | Phase I; phase II ongoing | |
BLyS | Belimumab | Phase III completed | |
| Â | A-623 | Phase I; phase II suspended/restarted | [123] |
| Â | LY2127399 | Phase III planned | [125] |
BLyS and APRIL | Atacicept | Phase II/III initiated | [122] |