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Table 3 Top 15 deviated functional categories of underexpressed genes in rheumatoid arthritis bone marrow compared with osteoarthritis bone marrow

From: Abnormal networks of immune response-related molecules in bone marrow cells from patients with rheumatoid arthritis as revealed by DNA microarray analysis

Gene category

List hits

Population hits

EASE score

(GO biological process)

(Total = 733)

(Total = 10,937)

 

cell proliferation

139

1036

4.05E-16

   cell cycle

127

690

1.06E-26

   mitotic cell cycle

97

329

2.78E-37

   M phase

48

157

3.98E-19

   nuclear division

47

151

4.40E-19

   mitosis

44

121

7.91E-21

   regulation of mitosis

11

26

3.37E-06

   regulation of cell cycle

64

384

1.83E-11

   cell cycle checkpoint

15

35

1.98E-08

   cytokinesis

26

95

1.83E-09

DNA replication and chromosome cycle

52

186

8.28E-19

   DNA replication

40

146

2.96E-14

   DNA dependent DNA replication

23

75

1.86E-09

DNA metabolism

85

517

1.02E-14

   nucleocytoplasmic transport

21

97

5.06E-06

  1. EASE, Expression Analysis Systematic Explorer software, Version 2.0; Gene Ontology database; GO, gene ontology.
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Arthritis Research & Therapy

ISSN: 1478-6362

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