Figure 5
From: Oestrogen deficiency modulates particle-induced osteolysis
Effect of polyethylene particles on calvariae, as assessed by histology. Representative stained calvarial histology (Stevenel Blue, picrofuschine) is presented at Ă—20 original magnification (n = 7 per group). Polyethylene particles induced osteolysis, characterized by a consistent decrease in calvarial bone thickness and an inflammatory response (arrowheads) in normal controls (NC), sham-ovariectomized (OVX) mice and OVX mice supplemented with oestrogen (E), while it was moderate in OVX mice. PE(-): sham-implanted; PE(+): PE-implanted.